Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions.
Article Details
- CitationCopy to clipboard
Toussaint JL, Geoffroy V, Schmitt M, Werner A, Garnier JM, Simoni P, Kempf J
Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions.
Genomics. 1992 Feb;12(2):412-6.
- PubMed ID
- 1339386 [ View in PubMed]
- Abstract
Choline acetyltransferase (CHAT) (EC 2.3.1.6) is the biosynthetic enzyme for the neurotransmitter acetylcholine in the central and peripheral nervous systems. In this study, a human CHAT genomic clone has been isolated and partially sequenced at its 5' end. This fragment contains the first four exons with an ACG initiator codon and potential control regions including TATA, CAAT, GC boxes, and several transcription control sequences. A comparison of the primary structure of CHAT among pig, rat, mouse, and Drosophila is presented.