Atomic structure and chemistry of human serum albumin.

Article Details

Citation

He XM, Carter DC

Atomic structure and chemistry of human serum albumin.

Nature. 1992 Jul 16;358(6383):209-15.

PubMed ID
1630489 [ View in PubMed
]
Abstract

The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Serum albuminP02768Details