Management of radiation-induced nausea and vomiting.

Article Details

Citation

Copy to clipboard

Abdelsayed GG

Management of radiation-induced nausea and vomiting.

Exp Hematol. 2007 Apr;35(4 Suppl 1):34-6.

PubMed ID

17379085 [ View in PubMed

]

Abstract

Management of radiation-induced nausea and vomiting (RINV) includes both prevention and therapy. Primary prevention involves implementation of measures to modify risk factors. Secondary prevention involves prophylaxis and treatment with 5HT(3) receptor antagonists (5HT(3)RAs) with or without corticosteroids, dopamine antagonists, antihistamines, or anticholinergics. 5HT(3)RAs are also useful in treatment of RINV with significantly better outcomes, compared to other antiemetics or placebo. Agents include ondansetron, granisetron, dolasetron, palonosetron, and tropisitron. These agents may be useful in both the radiotherapy patient and the individual who has been accidentally exposed to ionizing radiation.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Granisetron	5-hydroxytryptamine receptor 3A	Protein	Humans	Yes	Antagonist	Details