Ondansetron hydrochloride: a competitive serotonin 5-HT3 receptor blocker.

Article Details

Citation

Mohan KC, Ravikumar K

Ondansetron hydrochloride: a competitive serotonin 5-HT3 receptor blocker.

Acta Crystallogr C. 1995 Dec 15;51 ( Pt 12):2627-9.

PubMed ID
8588861 [ View in PubMed
]
Abstract

The methyl substituted imidazole ring in the title compound, 2-methyl-1-(9-methyl-4-oxo-2,3,4,9-tetrahydro-1H-carbazol-3-yl) imidazol-3-ium chloride dihydrate, C18H20N3O+.Cl-.2H2O, is approximately perpendicular to the carbazole plane [dihedral angle 87.0(1) degrees]. The water molecules are involved in an elaborate network of hydrogen bonds that reinforce the stability of the dihydrate and the cohesion of the structure.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Ondansetron5-hydroxytryptamine receptor 3AProteinHumans
Yes
Antagonist
Details