The mechanism of isoniazid killing: clarity through the scope of genetics.

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Vilcheze C, Jacobs WR Jr

The mechanism of isoniazid killing: clarity through the scope of genetics.

Annu Rev Microbiol. 2007;61:35-50.

PubMed ID

18035606 [ View in PubMed

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Abstract

Isoniazid (INH) is one of the most efficient drugs for the treatment of Mycobacterium tuberculosis infections. Despite its rather simple chemical structure, the mechanism by which INH kills M. tuberculosis is complex. A full understanding of the mechanisms of action of INH required the development of genetic tools in M. tuberculosis. Herein, we discuss the different hypotheses that have been used to describe INH action against M. tuberculosis over the past 50 years in terms of the pregenetic and genetic era. We also review the different mechanisms of INH resistance and propose what we think is the means by which INH kills M. tuberculosis.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Isoniazid	Catalase-peroxidase	Protein	Mycobacterium tuberculosis	Yes	Other/unknown	Details
Isoniazid	Enoyl-[acyl-carrier-protein] reductase [NADH]	Protein	Mycobacterium tuberculosis	Yes	Adduct	Details