CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.
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Vincent MS, Xiong X, Grant EP, Peng W, Brenner MB
CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.
J Immunol. 2005 Nov 15;175(10):6344-51.
- PubMed ID
- 16272286 [ View in PubMed]
- Abstract
Individual CD1-restricted T cells can recognize either endogenous or foreign lipid Ags, but the extent to which the same CD1-restricted TCR can react to both self and microbial lipids is unknown. In this study, we have identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-gamma in response to self-CD1 expressed on monocyte-derived dendritic cells. Remarkably, microbial Ags presented by CD1 are even more potent agonists for these same T cells. The alphabeta T cell receptors from such clones are diverse and confer specificity for both self-CD1 and foreign lipid Ags. The dual reactivity of these CD1-restricted cells suggests that the capacity for rapid responses to inflammatory stimuli without memory coexists with the capacity for strong Ag-specific responses and the generation of memory in vivo.