Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor.

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Citation

Hu X, Emanuel PD, Zuckerman KS

Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor.

Biochim Biophys Acta. 1994 Sep 8;1223(2):306-8.

PubMed ID
8086503 [ View in PubMed
]
Abstract

Two distinct cDNA clones, corresponding to alternative mRNA splicing variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSF-R alpha) were isolated from human blood mononuclear cells by RT-PCR. The first one lacks 179 bp, and the second one lacks 136 bp of the major variant, GM-CSF-R alpha 1. Both of variants result in shifts in the reading frame and are expected to encode 377- and 285-amino-acid membrane anchoring and soluble receptor isoforms, respectively.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Granulocyte-macrophage colony-stimulating factor receptor subunit alphaP15509Details