Globin chain synthesis in hemolytic anemia reticulocytes. A case of hemoglobin Burke.
Article Details
- CitationCopy to clipboard
Suzuki H, Wada C, Kamata K, Takahashi E, Sato N, Kunitomo T
Globin chain synthesis in hemolytic anemia reticulocytes. A case of hemoglobin Burke.
Biochem Mol Biol Int. 1993 Jul;30(3):425-31.
- PubMed ID
- 8401300 [ View in PubMed]
- Abstract
Peripheral red blood cells from an anemic patient were incubated with [14C]Leu and the labeled globin chains were analyzed by CM-cellulose column chromatography in 8M urea. The radioactivity almost equal to that of beta chain emerged between beta and alpha chains. The newly appeared materials were found to be derived from an abnormal hemoglobin (Hb), Hb Burke [beta 107(G9)Gly to Arg], by the sequence analyses of abnormal globin chain and beta globin mRNA from the patient.