Sites of acetylation of sickle cell hemoglobin by aspirin.
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Shamsuddin M, Mason RG, Ritchey JM, Honig GR, Klotz IM
Sites of acetylation of sickle cell hemoglobin by aspirin.
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4693-7.
- PubMed ID
- 4531009 [ View in PubMed]
- Abstract
Aspirin acetylates a variety of sites on both the alpha and beta chains of hemoglobin S. Nevertheless, the vast majority of acetyl groups become attached to three loci: betaLys 59, betaLys 144, and alphaLys 90. These observations reveal some molecular details of this transacylation reaction and suggest interesting possibilities for its extension to other acylsalicylates with a variety of different structures.