Effect of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist, on motor performance in mice.
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Miyamoto M
Effect of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist, on motor performance in mice.
Neurosci Lett. 2006 Jul 24;402(3):201-4. Epub 2006 May 24.
- PubMed ID
- 16730121 [ View in PubMed]
- Abstract
Effect of (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide (ramelteon, TAK-375), a selective MT1/MT2 receptor agonist, on motor coordination was studied using rota-rod performance in mice. Ramelteon did not impair rota-rod performance at doses of 3, 10 and 30 mg/kg, p.o. Melatonin and N-acetyl-5-hydroxytryptamine (N-acetyl-5-HT), a ligand of MT3 biding site, also had no impairment on the performance, per se. However, in combination with a low dose of diazepam (3mg/kg, p.o.), treatment with melatonin and N-acetyl-5-HT exacerbated the impairment by diazepam. Ramelteon had no significant effect on the diazepam-induced impairment of motor coordination.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ramelteon Melatonin receptor type 1A Protein Humans YesMultitargetDetails Ramelteon Melatonin receptor type 1B Protein Humans YesMultitargetDetails