Isotretinoin revisited: pluripotent effects on human sebaceous gland cells.

Article Details

Citation

Zouboulis CC

Isotretinoin revisited: pluripotent effects on human sebaceous gland cells.

J Invest Dermatol. 2006 Oct;126(10):2154-6.

PubMed ID
16983322 [ View in PubMed
]
Abstract

Nelson et al. confirmed the previously described antiproliferative effect of isotretinoin on human sebocytes. They attributed a portion of this decrease to cell cycle arrest and detected sebocyte apoptosis, which was not recapitulated by alitretinoin or tretinoin. These events were specific to sebocytes, as isotretinoin failed to induce apoptosis in keratinocytes. Isotretinoin-induced apoptosis was shown to be an RAR-independent mechanism.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
IsotretinoinRetinoic acid receptor alphaProteinHumans
Unknown
Other/unknown
Details