Isotretinoin revisited: pluripotent effects on human sebaceous gland cells.
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Zouboulis CC
Isotretinoin revisited: pluripotent effects on human sebaceous gland cells.
J Invest Dermatol. 2006 Oct;126(10):2154-6.
- PubMed ID
- 16983322 [ View in PubMed]
- Abstract
Nelson et al. confirmed the previously described antiproliferative effect of isotretinoin on human sebocytes. They attributed a portion of this decrease to cell cycle arrest and detected sebocyte apoptosis, which was not recapitulated by alitretinoin or tretinoin. These events were specific to sebocytes, as isotretinoin failed to induce apoptosis in keratinocytes. Isotretinoin-induced apoptosis was shown to be an RAR-independent mechanism.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Isotretinoin Retinoic acid receptor alpha Protein Humans UnknownOther/unknownDetails