[Effect of nandrolone phenylpropionate on expression of hepatic albumin-mRNA and androgen receptor in burned rats].

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Cen Y, Li K, Liu XX

[Effect of nandrolone phenylpropionate on expression of hepatic albumin-mRNA and androgen receptor in burned rats].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2003 Nov;17(6):439-41.

PubMed ID

14663936 [ View in PubMed

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Abstract

OBJECTIVE: To study the mechanism of nandrolone phenylpropionate (NP) on hepatic albumin mRNA and androgen receptor(AR) in burned rats. METHODS: Thirty-two Wistar rats with a deep second-degree cutaneous burn of 20% total body surface area were randomly divided into two groups: NP group (experimental group, 5 mg/kg NP) and normal saline as control group every other day. The expression copy quantity of albumin-mRNA and mean integrated absorbency(mIA) of AR in liver tissue were measured by quantitative fluorescent RT-PCR and immunohistochemistry respectively on the 4th, 7th, 14th and 21st days of post-burned. RESULTS: The expression levels of albumin-mRNA and AR in liver tissue in NP group were much higher than those in control group. The albumin-mRNA and AR expression increased significantly (P < 0.05) after 7 and 14 days, while the expression had no significant difference between NP group and control group on the 4th day. A positive correlation occurred between the expression level of albumin-mRNA and the quantity of AR in liver tissue(r = 0.936, P < 0.05). CONCLUSION: Nandrolone phenylpropionate up-regulated respectively the expression of albumin-mRNA and the density of AR in liver tissue.

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Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Nandrolone phenpropionate	Androgen receptor	Protein	Humans	Yes	Agonist	Details