Hemoglobin saitama or beta 117 (G19) His leads to Pro, a new variant causing hemolytic disease.
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Ohba Y, Hasegawa Y, Amino H, Miwa S, Nakatsuji T, Hattori Y, Miyaji T
Hemoglobin saitama or beta 117 (G19) His leads to Pro, a new variant causing hemolytic disease.
Hemoglobin. 1983;7(1):47-56.
- PubMed ID
- 6687721 [ View in PubMed]
- Abstract
An electrophoretically silent unstable hemoglobin was found in a 23-year-old Japanese woman suffering from hemolytic anemia and jaundice. The unstable beta subunit was precipitated with p-chloromercuribenzoic acid and the globin was further purified by urea CM-52 column chromatography. Results of amino acid analysis, tryptic fingerprinting and manual Edman degradation of the abnormal beta T12B established a substitution of proline for histidine beta 117 (G19). This new abnormal hemoglobin was absent in other members of the family.