B-raf, a new member of the raf family, is activated by DNA rearrangement.

Article Details

Citation

Ikawa S, Fukui M, Ueyama Y, Tamaoki N, Yamamoto T, Toyoshima K

B-raf, a new member of the raf family, is activated by DNA rearrangement.

Mol Cell Biol. 1988 Jun;8(6):2651-4.

PubMed ID
3043188 [ View in PubMed
]
Abstract

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Serine/threonine-protein kinase B-rafP15056Details