B-raf, a new member of the raf family, is activated by DNA rearrangement.
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Ikawa S, Fukui M, Ueyama Y, Tamaoki N, Yamamoto T, Toyoshima K
B-raf, a new member of the raf family, is activated by DNA rearrangement.
Mol Cell Biol. 1988 Jun;8(6):2651-4.
- PubMed ID
- 3043188 [ View in PubMed]
- Abstract
Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.