Evidence that an alpha 2A-adrenoceptor subtype mediates antinociception in mice.
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Millan MJ
Evidence that an alpha 2A-adrenoceptor subtype mediates antinociception in mice.
Eur J Pharmacol. 1992 May 14;215(2-3):355-6.
- PubMed ID
- 1356794 [ View in PubMed]
- Abstract
In the hot-plate test in mice, the antinociceptive action of the alpha 2-adrenoceptor agonist, UK 14,304, was abolished by the alpha 2-adrenoceptor antagonist, idazoxan, the potent alpha 2A-adrenoceptor antagonist, RX 821002 and the preferential alpha 2A-adrenoceptor antagonist, BRL 44408. In contrast, the preferential alpha 2B- (and alpha 2C)-adrenoceptor ligands ('antagonists'), ARC-239, BRL 41992 and prazosin were inactive. The preferential alpha 2A-adrenoceptor partial agonist, guanfacine, partially inhibited UK 14,304-induced antinociception. Further, guanfacine BRL 44408 reversibly elicited submaximal antinociception. It is concluded that alpha 2A-adrenoceptors mediate antinociception in mice.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Guanfacine Alpha-2A adrenergic receptor Protein Humans YesAgonistDetails