A human retinoic acid receptor which belongs to the family of nuclear receptors.

Article Details

Citation

Petkovich M, Brand NJ, Krust A, Chambon P

A human retinoic acid receptor which belongs to the family of nuclear receptors.

Nature. 1987 Dec 3-9;330(6147):444-50.

PubMed ID
2825025 [ View in PubMed
]
Abstract

A cDNA encoding a protein that binds retinoic acid with high affinity has been cloned. The protein is homologous to the receptors for steroid hormones, thyroid hormones and vitamin D3, and appears to be a retinoic acid-inducible trans-acting enhancer factor, suggesting that the molecular mechanisms of the effect of retinoids (vitamin A) on embryonic development, differentiation and tumour cell growth are similar to those described for other members of this nuclear receptor family.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Retinoic acid receptor alphaP10276Details