Irbesartan: a review of its use in hypertension and diabetic nephropathy.

Article Details

Citation

Croom KF, Plosker GL

Irbesartan: a review of its use in hypertension and diabetic nephropathy.

Drugs. 2008;68(11):1543-69.

PubMed ID
18627212 [ View in PubMed
]
Abstract

Irbesartan (Aprovel, Avapro, Irbetan, Karvea), an angiotensin II receptor type 1 antagonist, is approved in many countries worldwide for the treatment of hypertension. It is also approved in some regions for the treatment of nephropathy in patients with hypertension and type 2 diabetes mellitus. In adults with essential hypertension, irbesartan is effective at reducing blood pressure (BP) over a 24-hour period with once-daily administration. Irbesartan also slows the progression of renal disease in hypertensive patients with type 2 diabetes, with this effect partly independent of its BP-lowering effect. In addition, irbesartan was generally well tolerated in clinical trials. Thus, irbesartan is a useful treatment option for patients with hypertension, including those with type 2 diabetes and nephropathy.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
IrbesartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details