[Acetylsalicylic acid resistance--clinical diagnosis with unclear mechanism].

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Hillarp A

[Acetylsalicylic acid resistance--clinical diagnosis with unclear mechanism].

Lakartidningen. 2004 Nov 4;101(45):3504-6, 3508-9.

PubMed ID

15575422 [ View in PubMed

]

Abstract

A review on the subject of aspirin resistance and its role in vascular diseases is presented. Although the clinical diagnosis of aspirin resistance is frequently made, little is known about its biochemical background. Only a few follow-up studies, with varying design, have dealt with the possible association between an aspirin resistant phenotype and clinical outcome in patients with atherothrombosis. However, it was recently shown that ibuprofen acts as a competitive inhibitor in the blockage of COX-1. This pharmacodynamic interaction results in secondary aspirin resistance, which may have clinical significance in patients taking both medicines. With the complex nature of vascular diseases in mind, it is not surprising that aspirin used as a single preventive strategy fails in many cases. At present, there is no clear evidence that treatment failure is associated with a particular aspirin resistant phenotype.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ibuprofen	Prostaglandin G/H synthase 1	Protein	Humans	Yes	Inhibitor	Details
Tiaprofenic acid	Prostaglandin G/H synthase 1	Protein	Humans	Yes	Inhibitor	Details