Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors.

Article Details

Citation

Gautschi P, Frater-Schroder M, Bohlen P

Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors.

FEBS Lett. 1986 Aug 18;204(2):203-7.

PubMed ID
3732516 [ View in PubMed
]
Abstract

Two endothelial cell growth factors have been isolated from human brain extracts by a procedure involving heparin-Sepharose affinity chromatography and reverse-phase HPLC. On the basis of molecular size, amino acid composition and extended amino-terminal sequences, the two proteins are structurally closely related to bovine acidic and basic fibroblast growth factors (aFGF, bFGF). The N-terminal sequences of human and bovine aFGF differ in two positions while those for bFGF are indistinguishable. Human aFGF is microheterogenous: in addition to aFGF two N-terminally truncated forms lacking the first and the seven first amino acids, respectively, were characterized. Human and bovine mitogens possess similar mitogenic activities.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Fibroblast growth factor 1P05230Details
Fibroblast growth factor 2P09038Details