Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.
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Pennica D, Nedwin GE, Hayflick JS, Seeburg PH, Derynck R, Palladino MA, Kohr WJ, Aggarwal BB, Goeddel DV
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.
Nature. 1984 Dec 20-1985 Jan 2;312(5996):724-9.
- PubMed ID
- 6392892 [ View in PubMed]
- Abstract
Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.