Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.

Article Details

Citation

Pennica D, Nedwin GE, Hayflick JS, Seeburg PH, Derynck R, Palladino MA, Kohr WJ, Aggarwal BB, Goeddel DV

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.

Nature. 1984 Dec 20-1985 Jan 2;312(5996):724-9.

PubMed ID
6392892 [ View in PubMed
]
Abstract

Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Tumor necrosis factorP01375Details