Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.

Article Details

Citation

Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J, et al.

Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.

Nat Genet. 1993 Feb;3(2):137-45.

PubMed ID
8499947 [ View in PubMed
]
Abstract

We have conducted a detailed structural analysis of 90 kilobases (kb) of the HLA Class III region from the Bat2 gene at the centromeric end to 23 kb beyond TNF. A single contig of 80 kb was sequenced entirely with a group of four smaller contigs covering 10 kb being only partly sequenced. This region contains four known genes and a novel telomeric potential coding region. The genes are bracketed by long, dense clusters of Alu repeats belonging to all the major families. At least six new families of MER repeats and one pseudogene are intercalated within and between the Alu clusters. The most telomeric 3.8 kb contains three potential exons, one of which bears strong homology to the ankyrin domain of the DNA binding factors NF kappa B and I kappa B.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Tumor necrosis factorP01375Details
Lymphotoxin-alphaP01374Details