Structure of tumour necrosis factor.
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Jones EY, Stuart DI, Walker NP
Structure of tumour necrosis factor.
Nature. 1989 Mar 16;338(6212):225-8.
- PubMed ID
- 2922050 [ View in PubMed]
- Abstract
Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural motif characteristic of viral coat proteins.