Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.

Article Details

Citation

Inagaki N, Gonoi T, Clement JP 4th, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J

Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.

Science. 1995 Nov 17;270(5239):1166-70.

PubMed ID
7502040 [ View in PubMed
]
Abstract

A member of the inwardly rectifying potassium channel family was cloned here. The channel, called BIR (Kir6.2), was expressed in large amounts in rat pancreatic islets and glucose-responsive insulin-secreting cell lines. Coexpression with the sulfonylurea receptor SUR reconstituted an inwardly rectifying potassium conductance of 76 picosiemens that was sensitive to adenosine triphosphate (ATP) (IKATP) and was inhibited by sulfonylureas and activated by diazoxide. The data indicate that these pancreatic beta cell potassium channels are a complex composed of at least two subunits--BIR, a member of the inward rectifier potassium channel family, and SUR, a member of the ATP-binding cassette superfamily. Gene mapping data show that these two potassium channel subunit genes are clustered on human chromosome 11 at position 11p15.1.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
ATP-sensitive inward rectifier potassium channel 11Q14654Details