Molecular cloning of a levocabastine-sensitive neurotensin binding site.
Article Details
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Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D
Molecular cloning of a levocabastine-sensitive neurotensin binding site.
FEBS Lett. 1996 May 20;386(2-3):91-4.
- PubMed ID
- 8647296 [ View in PubMed]
- Abstract
A search for sequences homologous to the neurotensin receptor cDNA in a rat hypothalamic library has identified a novel neurotensin receptor (NTR-2). The 1539 bp cDNA encodes a 416 amino acid protein and shows highest homology to the previously cloned neurotensin receptor (NTR-1) (64% homology and 43% identity). Binding and pharmacological studies demonstrate that NTR-2 expressed in COS cells recognizes neurotensin (NT) with high affinity as well as several other agonists and antagonists. However, a fundamental difference was found; unlike NTR-1, NTR-2 recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with NT for low-affinity binding sites in brain.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Levocabastine Histamine H1 receptor Protein Humans YesAntagonistDetails Levocabastine Neurotensin receptor type 2 Protein Humans YesPartial antagonistDetails