[Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)].

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Szabo Z, Argyelan M, Kanyo B, Pavics L, Janka Z

[Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)].

Neuropsychopharmacol Hung. 2004 Jun;6(2):79-81.

PubMed ID

15787205 [ View in PubMed

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Abstract

Bupropion has an antidepressant effect through blocking the dopamine transporter. By 99mTc-TRODAT-SPECT, we measured the baseline DAT activity of depressed patients. After 3 weeks' bupropion treatment we studied the change in DAT activity, which corresponds to the occupancy of bupropion. The average occupancy of bupropion on DAT was similar to the international findings at 20.84% in 9 depressed patients.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Bupropion	Sodium-dependent dopamine transporter	Protein	Humans	Yes	Inhibitor	Details