Antidote use in the critically ill poisoned patient.
Article Details
- CitationCopy to clipboard
Betten DP, Vohra RB, Cook MD, Matteucci MJ, Clark RF
Antidote use in the critically ill poisoned patient.
J Intensive Care Med. 2006 Sep-Oct;21(5):255-77.
- PubMed ID
- 16946442 [ View in PubMed]
- Abstract
The proper use of antidotes in the intensive care setting when combined with appropriate general supportive care may reduce the morbidity and mortality associated with severe poisonings. The more commonly used antidotes that may be encountered in the intensive care unit (N-acetylcysteine, ethanol, fomepizole, physostigmine, naloxone, flumazenil, sodium bicarbonate, octreotide, pyridoxine, cyanide antidote kit, pralidoxime, atropine, digoxin immune Fab, glucagon, calcium gluconate and chloride, deferoxamine, phytonadione, botulism antitoxin, methylene blue, and Crotaline snake antivenom) are reviewed. Proper indications for their use and knowledge of the possible adverse effects accompanying antidotal therapy will allow the physician to appropriately manage the severely poisoned patient.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Digoxin Immune Fab (Ovine) Digoxin Small molecule Humans YesOther/unknownDetails Fomepizole Alcohol dehydrogenase 1A Protein Humans YesInhibitorDetails Fomepizole Alcohol dehydrogenase 1B Protein Humans YesInhibitorDetails Fomepizole Alcohol dehydrogenase 1C Protein Humans YesInhibitorDetails