Role of HIV-1 Gag domains in viral assembly.

Article Details


Scarlata S, Carter C

Role of HIV-1 Gag domains in viral assembly.

Biochim Biophys Acta. 2003 Jul 11;1614(1):62-72.

PubMed ID
12873766 [ View in PubMed

After entry of the human immunodeficiency virus type 1 (HIV-1) into T cells and the subsequent synthesis of viral products, viral proteins and RNA must somehow find each other in the host cells and assemble on the plasma membrane to form the budding viral particle. In this general review of HIV-1 assembly, we present a brief overview of the HIV life cycle and then discuss assembly of the HIV Gag polyprotein on RNA and membrane substrates from a biochemical perspective. The role of the domains of Gag in targeting to the plasma membrane and the role of the cellular host protein cyclophilin are also reviewed.

DrugBank Data that Cites this Article

NameUniProt ID
Gag-Pol polyproteinP03369Details
Gag-Pol polyproteinP12497Details
Gag-Pol polyproteinP35963Details
Gag-Pol polyproteinP12499Details
Gag-Pol polyproteinP04585Details
Gag-Pol polyproteinP03366Details
Gag-Pol polyproteinP03367Details
Gag-Pol polyproteinP04587Details