The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
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Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A
The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
Nature. 1997 Nov 20;390(6657):249-56.
- PubMed ID
- 9384377 [ View in PubMed]
- Abstract
Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding genes, 53% are represented once, while a quarter of the genome corresponds to several gene families that have been greatly expanded by gene duplication, the largest family containing 77 putative ATP-binding transport proteins. In addition, a large proportion of the genetic capacity is devoted to the utilization of a variety of carbon sources, including many plant-derived molecules. The identification of five signal peptidase genes, as well as several genes for components of the secretion apparatus, is important given the capacity of Bacillus strains to secrete large amounts of industrially important enzymes. Many of the genes are involved in the synthesis of secondary metabolites, including antibiotics, that are more typically associated with Streptomyces species. The genome contains at least ten prophages or remnants of prophages, indicating that bacteriophage infection has played an important evolutionary role in horizontal gene transfer, in particular in the propagation of bacterial pathogenesis.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Penicillin-binding protein 3 P42971 Details 2,3-dihydroxybenzoate-AMP ligase P40871 Details Adenylate kinase P16304 Details Hut operon positive regulatory protein P10943 Details Ferrochelatase P32396 Details Maltose-6'-phosphate glucosidase P54716 Details Thiamine-phosphate synthase P39594 Details Phosphocarrier protein HPr P08877 Details Amidophosphoribosyltransferase P00497 Details Alpha-amylase P00691 Details Nitric oxide synthase oxygenase O34453 Details Chorismate mutase AroH P19080 Details S-ribosylhomocysteine lyase O34667 Details Isocitrate dehydrogenase [NADP] P39126 Details Septum formation protein Maf Q02169 Details Aminopyrimidine aminohydrolase P25052 Details Thiazole tautomerase P25053 Details Glycine oxidase O31616 Details NH(3)-dependent NAD(+) synthetase P08164 Details Glycerol-3-phosphate cytidylyltransferase P27623 Details Pur operon repressor P37551 Details Ribose-phosphate pyrophosphokinase P14193 Details N-acetylglucosamine-6-phosphate deacetylase O34450 Details Nicotinate-nucleotide adenylyltransferase P54455 Details Spermidine/spermine N(1)-acetyltransferase P21340 Details Glucosamine-6-phosphate deaminase 1 O35000 Details 6,7-dimethyl-8-ribityllumazine synthase P11998 Details GTPase Obg P20964 Details Xanthine phosphoribosyltransferase P42085 Details Holo-[acyl-carrier-protein] synthase P96618 Details Probable GTP-binding protein EngB P38424 Details Hydroxyethylthiazole kinase P39593 Details Phosphate acetyltransferase P39646 Details Sigma factor SigB regulation protein RsbQ O07015 Details Spore coat polysaccharide biosynthesis protein SpsA P39621 Details D-ribose pyranase P36946 Details Orotidine 5'-phosphate decarboxylase P25971 Details Fatty-acid peroxygenase O31440 Details Cytidine deaminase P19079 Details Peptidoglycan-N-acetylmuramic acid deacetylase PdaA O34928 Details Protein IolS P46336 Details Putative mannose-6-phosphate isomerase YvyI P39841 Details Oxalate decarboxylase OxdC O34714 Details Glutaminase 1 O31465 Details Uncharacterized N-acetyltransferase YvbK O32248 Details 4'-phosphopantetheinyl transferase sfp P39135 Details Endoribonuclease EndoA P96622 Details Levansucrase P05655 Details Manganese-dependent inorganic pyrophosphatase P37487 Details Putative monooxygenase MoxC O34974 Details Protein NrdI P50618 Details FMN-dependent NADPH-azoreductase O07529 Details Isopentenyl-diphosphate delta-isomerase P50740 Details Fatty acid metabolism regulator protein P94548 Details Guanine deaminase O34598 Details General stress protein 69 P80874 Details Ribonuclease Z P54548 Details Transcription antiterminator LicT P39805 Details Protoporphyrinogen oxidase P32397 Details Biotin/lipoyl attachment protein C0H419 Details Biotin biosynthesis cytochrome P450 P53554 Details Beta-hexosaminidase P40406 Details Bacilysin biosynthesis protein BacB P39639 Details Lipase EstA P37957 Details Thymidylate synthase 1 P0CI79 Details DNA topoisomerase 4 subunit B Q59192 Details DNA gyrase subunit A P05653 Details