Aripiprazole acts as a selective dopamine D2 receptor partial agonist.
Article Details
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Wood M, Reavill C
Aripiprazole acts as a selective dopamine D2 receptor partial agonist.
Expert Opin Investig Drugs. 2007 Jun;16(6):771-5.
- PubMed ID
- 17501690 [ View in PubMed]
- Abstract
Aripiprazole has made a significant contribution to the treatment of schizophrenia and related disorders with an improved safety and tolerability profile, which has been attributed to its unique pharmacological profile. It has been claimed that partial agonism of the dopamine D(2) and 5-HT(1A) receptors and antagonism of the 5-HT(2) receptor contribute to the clinical profile of aripiprazole, a so-called dopamine- and 5-HT stabiliser. However, recent studies have questioned the role of the 5-HT-mediated systems in the mechanism of action of aripiprazole. This report reviews published and unpublished data that suggest that aripiprazole acts as a selective partial agonist at the dopamine D(2) receptor and does not affect 5-HT receptors at therapeutic doses.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Aripiprazole Dopamine D2 receptor Protein Humans YesAntagonistPartial agonistDetails Aripiprazole lauroxil Dopamine D2 receptor Protein Humans YesPartial agonistDetails