Chemotherapy for androgen-independent prostate cancer.

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Petrylak DP

Chemotherapy for androgen-independent prostate cancer.

World J Urol. 2005 Feb;23(1):10-3. Epub 2005 Feb 1.

PubMed ID
15685445 [ View in PubMed
]
Abstract

The evolution of taxanes as treatment for androgen-independent prostate cancer hes emerged from both the laboratory and clinic. Docetaxel is a potent in vitro inhibitor of Bcl-2, an antiapoptotic gene. Phase I and II studies with docetaxel alone or in combination with estramustine demonstrated promissing median survivals of 14--23 months, higher than what would have been expected for historic controls. Two randomized trials have proven the superiority of docetaxel based treatment in improving survival in men with androgen-independent prostate cancer. SWOG 99-16 and TAX 327 found that docetaxel-based therapy reduced the risk of death by 20--24% when compared to mitoxantrone-based therapy. Future trials will build on docetaxel-based combinations with novel targeted agents.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
DocetaxelApoptosis regulator Bcl-2ProteinHumans
Unknown
Not AvailableDetails