Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
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Wallace MB, Adams ME, Kanouni T, Mol CD, Dougan DR, Feher VA, O'Connell SM, Shi L, Halkowycz P, Dong Q
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
Bioorg Med Chem Lett. 2010 Jul 15;20(14):4156-8. doi: 10.1016/j.bmcl.2010.05.058. Epub 2010 May 20.
- PubMed ID
- 20621728 [ View in PubMed]
- Abstract
A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties.