Amisulpride-induced seizurogenic effect: a potential role of opioid receptor-linked transduction systems.

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Rehni AK, Singh TG, Chand P

Amisulpride-induced seizurogenic effect: a potential role of opioid receptor-linked transduction systems.

Basic Clin Pharmacol Toxicol. 2011 May;108(5):310-7. doi: 10.1111/j.1742-7843.2010.00655.x. Epub 2010 Dec 22.

PubMed ID
21176108 [ View in PubMed
]
Abstract

This study was designed to investigate the role of opioid receptors, gamma-aminobutyric acid (GABA) receptors, mast cells and histamine receptors (H(1) subtype) in the seizurogenic effect of amisulpride on mice. A single injection of amisulpride (180 mg/kg) was employed to evaluate the seizurogenicity of the drug in mice. Seizures were assessed in terms of a composite seizure severity score (SSS), time of the onset of straub-like tail, onset of jerky movements of whole body, convulsions and death. Amisulpride administration (180 mg/kg) induced a significant pro-convulsant effect in mice as measured in terms of the SSS (21.12 +/- 2.71) and a significant decrease in the time latency of the onset of straub-like tail (132.45 +/- 12.31), jerky movements of whole body (153.28 +/- 14.12), convulsions (184.97 +/- 13.11) and death (100%). Moreover, prior administration of naloxone, cetrizine, sodium cromoglycate and gabapentin, respectively, attenuated this seizurogenic activity that amisulpride exerted on mice (p < 0.05). Therefore, it may be suggested that amisulpride exerts a seizurogenic effect on mice possibly via an opioid receptor activation-dependent release of histamine from the mast cells and a simultaneous inhibition of GABA release.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
AmisulprideDelta-type opioid receptorProteinHumans
No
Agonist
Details
AmisulprideKappa-type opioid receptorProteinHumans
No
Agonist
Details
AmisulprideMu-type opioid receptorProteinHumans
No
Agonist
Details