Pharmacokinetic evaluation of ambrisentan.
Article Details
- CitationCopy to clipboard
Buckley MS, Wicks LM, Staib RL, Kirejczyk AK, Varker AS, Gibson JJ, Feldman JP
Pharmacokinetic evaluation of ambrisentan.
Expert Opin Drug Metab Toxicol. 2011 Mar;7(3):371-80. doi: 10.1517/17425255.2011.557181. Epub 2011 Feb 8.
- PubMed ID
- 21299444 [ View in PubMed]
- Abstract
INTRODUCTION: Pulmonary arterial hypertension (PAH) is a life-threatening and progressive disease characterized by increasing pulmonary vascular resistance leading to right ventricular failure and premature death. Current therapies target three major pathways involving endothelin, prostacyclin and NO. Ambrisentan is an oral, once daily, selective endothelin receptor antagonist. AREAS COVERED: This review focuses on, and critically appraises, the clinical efficacy and safety of ambrisentan as well as its pharmacokinetic and pharmacodynamic properties. The article also gives an expert perspective on the role of ambrisentan in the management of PAH. EXPERT OPINION: Ambrisentan is an effective and safe treatment which is, in the authors' opinion, a valuable addition to the armamentarium against PAH. Ambrisentan offers a relative lack of drug interactions, once daily dosing and reassuring liver safety, offering safety and convenience advantages over bosentan. Presently, there is a lack of comparative studies between PDE5 inhibitors and endothelin receptor antagonists and a lack of data comparing bosentan with ambrisentan. This is hindering data-based conclusions regarding relative efficacy and further studies are needed to define the role of ambrisentan in the management of PAH.
DrugBank Data that Cites this Article
- Drugs
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Ambrisentan Cytochrome P450 2C19 Protein Humans UnknownSubstrateDetails Ambrisentan UDP-glucuronosyltransferase 1-3 Protein Humans UnknownSubstrateDetails Ambrisentan UDP-glucuronosyltransferase 1-9 Protein Humans UnknownSubstrateDetails Ambrisentan UDP-glucuronosyltransferase 2B7 Protein Humans UnknownSubstrateDetails