Androgen physiology.

Article Details

Citation

Copy to clipboard

Davison SL, Bell R

Androgen physiology.

Semin Reprod Med. 2006 Apr;24(2):71-7.

PubMed ID

16633980 [ View in PubMed

]

Abstract

Androgen receptors are present in numerous tissues throughout the female body, and knowledge of the specific actions of androgens at different sites is increasing, along with the understanding of their contribution to various pathophysiological states. This article reviews the physiology of androgens (testosterone and dihydrotestosterone) and immediate androgen precursors (dehydroepiandrosterone [DHEA], dehydroepiandrosterone sulfate [DHEAS], and androstenedione), with specific reference to the androgen receptor, production and metabolism of C- (19) steroids, circulating androgen concentrations, and androgen actions. In addition, the evidence for physiological modulation of androgens including circadian variation, cyclical variation, age, and natural menopause is reviewed.

DrugBank Data that Cites this Article

Drugs

Oxymetholone

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Oxymetholone	Androgen receptor	Protein	Humans	Yes	Agonist Activator	Details

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Oxymetholone	3-oxo-5-alpha-steroid 4-dehydrogenase 1	Protein	Humans	No	Substrate Activator	Details