Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4.

Article Details

Citation

Jeyaraj S, Boehmer C, Lang F, Palmada M

Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4.

Biochem Biophys Res Commun. 2007 May 11;356(3):629-35. Epub 2007 Mar 12.

PubMed ID
17382906 [ View in PubMed
]
Abstract

Insulin stimulates glucose transport into muscle and fat cells by enhancing GLUT4 abundance in the plasma membrane through activation of phosphatidylinositol 3-kinase (PI3K). Protein kinase B (PKB) and PKCzeta are known PI3K downstream targets in the regulation of GLUT4. The serum- and glucocorticoid-inducible kinase SGK1 is similarly activated by insulin and capable to regulate cell surface expression of several metabolite transporters. In this study, we evaluated the putative role of SGK1 in the modulation of GLUT4. Coexpression of the kinase along with GLUT4 in Xenopus oocytes stimulated glucose transport. The enhanced GLUT4 activity was paralleled by increased transporter abundance in the plasma membrane. Disruption of the SGK1 phosphorylation site on GLUT4 ((S274A)GLUT4) abrogated the stimulating effect of SGK1. In summary, SGK1 promotes glucose transporter membrane abundance via GLUT4 phosphorylation at Ser274. Thus, SGK1 may contribute to the insulin and GLUT4-dependent regulation of cellular glucose uptake.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Solute carrier family 2, facilitated glucose transporter member 4P14672Details
Serine/threonine-protein kinase Sgk1O00141Details