Ceftaroline: a cephalosporin with expanded Gram-positive activity.

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Kanafani ZA, Corey GR

Ceftaroline: a cephalosporin with expanded Gram-positive activity.

Future Microbiol. 2009 Feb;4(1):25-33. doi: 10.2217/17460913.4.1.25.

PubMed ID
19207097 [ View in PubMed
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Abstract

Infections caused by resistant Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) are now posing a major health risk for patients in hospital and community settings. There is a need to evaluate new antibiotics that would offer reliable clinical efficacy combined with a favorable safety profile for the treatment of such infections. Ceftaroline is a new member of the cephalosporin class of antibiotics with expanded activity against Gram-positive pathogens such as MRSA, vancomycin-intermediate S. aureus, vancomycin-resistant S. aureus and multidrug-resistant Streptococcus pneumoniae, while retaining good activity against common Gram-negative organisms. Phase II and III studies have shown ceftaroline to be an effective and well-tolerated treatment for complicated skin and skin-structure infections compared with standard therapy. Trials are ongoing in the treatment of community-acquired pneumonia.

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