Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.

Article Details

Citation

Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA

Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.

Science. 1991 Feb 15;251(4995):802-4.

PubMed ID
1846706 [ View in PubMed
]
Abstract

Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the beta subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase. Covalent cross-linking of 125I-labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c-met directly established the c-met product as the cell-surface receptor for HGF.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Hepatocyte growth factor receptorP08581Details