Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase.

Article Details

Citation

Burke J, Hwang P, Anderson L, Lebo R, Gorin F, Fletterick R

Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase.

Proteins. 1987;2(3):177-87.

PubMed ID
3447177 [ View in PubMed
]
Abstract

The intron/exon organization of the human gene for glycogen phosphorylase has been determined. The segments of the polypeptide chain that corresponds to the 19 exons of the gene are examined for relationships between the three-dimensional structure to the protein and gene structure. Only weak correlations are observed between domains of phosphorylase and exons. The nucleotide binding domains that are found in phosphorylase and other glycolytic enzymes are examined for relationships between exons of the genes and structures of the domains. When mapped to the three-dimensional structures, the intron/exon boundaries are shown to be widely distributed in this family of protein domains.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Glycogen phosphorylase, muscle formP11217Details