Perioperative systemic haemostatic agents.

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Mahdy AM, Webster NR

Perioperative systemic haemostatic agents.

Br J Anaesth. 2004 Dec;93(6):842-58. Epub 2004 Jul 26.

PubMed ID
15277296 [ View in PubMed
]
Abstract

Skilful surgery combined with blood-saving methods and careful management of blood coagulation will all help reduce unnecessary blood loss and transfusion requirements. Excessive surgical bleeding causes hypovolaemia, haemodynamic instability, anaemia and reduced oxygen delivery to tissues, with a subsequent increase in postoperative morbidity and mortality. The role of anaesthetists in managing surgical blood loss has increased greatly in the last decade. Position of the patient during surgery and the provision of a hypotensive anaesthetic regimen were once considered the most important contributions of the anaesthetist to decreasing blood loss. Now, several pharmacological haemostatic agents are being used by anaesthetists as blood-saving agents. After a brief discussion of the physiology of haemostasis, this article will review the evidence for the role of such agents in reducing perioperative blood loss and transfusion requirements.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
AprotininChymotrypsinogen BProteinHumans
Unknown
Not AvailableDetails
AprotininKallikrein-1ProteinHumans
Unknown
Not AvailableDetails
AprotininPlasminogenProteinHumans
Unknown
Not AvailableDetails
AprotininTrypsin-1ProteinHumans
Unknown
Not AvailableDetails