Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

Article Details

Citation

Sharpe CR, Sidoli A, Shelley CS, Lucero MA, Shoulders CC, Baralle FE

Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

Nucleic Acids Res. 1984 May 11;12(9):3917-32.

PubMed ID
6328445 [ View in PubMed
]
Abstract

The structure and function of the genes encoding the polypeptide components of plasma lipoproteins are of interest because of the central role they play in the regulation of lipid metabolism. We have now completed our previous studies on the human apoAI gene and furthermore isolated and sequenced cDNA clones for apoAII , CII and CIII. The nucleotide sequences show the signal peptides of apoAII , CII and CIII to be 18, 22 and 20 amino acids in length, respectively, and in addition that prepro apoAII bears a classical propeptide structure of 5 amino acids. The amino acid homology detected between apoCII and pro- apoAI is discussed, as is the gene arrangement of the 5' non-coding region of apoAI mRNA. The relative liver mRNA levels of the 4 apolipoproteins analysed in this study have been estimated and compared with their corresponding plasma products. The data reported here provide an essential basis for further studies of structural and functional alleles of apo AI, AII, CII and CIII genes.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Apolipoprotein A-IIP02652Details
Apolipoprotein A-IP02647Details
Apolipoprotein C-IIP02655Details
Apolipoprotein C-IIIP02656Details