Prophylaxis of thromboembolism in general surgery: comparison between standard heparin and Fragmin.

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Hartl P, Brucke P, Dienstl E, Vinazzer H

Prophylaxis of thromboembolism in general surgery: comparison between standard heparin and Fragmin.

Thromb Res. 1990 Feb 15;57(4):577-84.

PubMed ID
2158151 [ View in PubMed
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Abstract

In a double blind randomized trial on 250 patients undergoing elective abdominal surgery the effect of Fragmin was compared with heparin. Patients over 40 years of age except appendectomy and herniotomy were included. The dose of heparin was 5,000 IU b.i.d. whilst Fragmin was given in a dose of 2,500 U once per day and the second injection was a placebo. Prophylaxis started 2 h preoperatively and was maintained for 7 days. The fibrinogen uptake test was used as a screening method for thrombosis which was confirmed by phlebography. 124 patients were in the heparin group and 126 in the Fragmin group. Comparability between groups was found in: age, sex, Broca index, amount and type of risk factors, type of surgery. Thromboembolism was found in 10 cases in each group. Blood transfusions on the postoperative days 1 to 6 were required in 2 Fragmin and in 12 heparin patients. The total amount of blood given during that time was 6 units in the Fragmin and 37 units in the heparin group. These differences were significant.

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