Structure and variation of human alpha 1-antitrypsin.
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Carrell RW, Jeppsson JO, Laurell CB, Brennan SO, Owen MC, Vaughan L, Boswell DR
Structure and variation of human alpha 1-antitrypsin.
Nature. 1982 Jul 22;298(5872):329-34.
- PubMed ID
- 7045697 [ View in PubMed]
- Abstract
The sequence of alpha 1-antitrypsin is in keeping with its role as a tissue scavenger of leukocyte elastase. Two abnormal variants commonly present in Europeans cause a deficiency that predisposes them to a progressive loss of lung elasticity. The nature of the reactive centre helps explain why cigarette smoking greatly accelerates the onset and severity of this degenerative process to give the disease emphysema.