Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin.
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Rallabhandi P, Hashimoto K, Mo YY, Beck WT, Moitra PK, D'Arpa P
Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin.
J Biol Chem. 2002 Oct 18;277(42):40020-6. Epub 2002 Jul 30.
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- 12149243 [ View in PubMed]
- Abstract
Previous studies identified a small fraction of putatively sumoylated topoisomerase I (TOP1) under basal conditions ( approximately 1%), and anticancer camptothecins that trap the TOP1-DNA covalent intermediate markedly increase the sumoylation of TOP1 (