Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin.

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Citation

Rallabhandi P, Hashimoto K, Mo YY, Beck WT, Moitra PK, D'Arpa P

Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin.

J Biol Chem. 2002 Oct 18;277(42):40020-6. Epub 2002 Jul 30.

PubMed ID
12149243 [ View in PubMed
]
Abstract

Previous studies identified a small fraction of putatively sumoylated topoisomerase I (TOP1) under basal conditions ( approximately 1%), and anticancer camptothecins that trap the TOP1-DNA covalent intermediate markedly increase the sumoylation of TOP1 (

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
DNA topoisomerase 1P11387Details