Regulation of beta-catenin signaling in the Wnt pathway.

Article Details

Citation

Kikuchi A

Regulation of beta-catenin signaling in the Wnt pathway.

Biochem Biophys Res Commun. 2000 Feb 16;268(2):243-8.

PubMed ID
10679188 [ View in PubMed
]
Abstract

beta-Catenin not only regulates cell to cell adhesion as a protein interacting with cadherin, but also functions as a component of the Wnt signaling pathway. The Wnt signaling pathway is conserved in various organisms from worms to mammals, and plays important roles in development, cellular proliferation, and differentiation. Wnt stabilizes cytoplasmic beta-catenin and then beta-catenin is translocated into the nucleus where it stimulates the expression of genes including c-myc, c-jun, fra-1, and cyclin D1. The amounts and functions of beta-catenin are regulated in both the cytoplasm and nucleus. Its molecular mechanisms are becoming increasingly well understood.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Catenin beta-1P35222Details