Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa.
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Buchanan MS, Carroll AR, Wessling D, Jobling M, Avery VM, Davis RA, Feng Y, Xue Y, Oster L, Fex T, Deinum J, Hooper JN, Quinn RJ
Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa.
J Med Chem. 2008 Jun 26;51(12):3583-7. doi: 10.1021/jm800314b.
- PubMed ID
- 18510371 [ View in PubMed]
- Abstract
Bioassay-guided fractionation of a CH2Cl2/MeOH extract of the sponge Suberea clavata using the serine protease factor XIa to detect antithrombotic activity led to the isolation of the new marine natural products, clavatadines A and B. Clavatadines A and B inhibited factor XIa with IC50's of 1.3 and 27 microM, respectively. A crystal structure of protein-inhibitor (clavatadine A) complex was obtained and revealed interesting selective binding and irreversible inhibition of factor XIa. The cocrystal structure provides guidance for the design and synthesis of future factor XIa inhibitors as antithrombotic agents.