Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.

Article Details

Citation

Begley GS, Horvath AR, Taylor JC, Higgins CF

Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.

Mol Immunol. 2005 Jan;42(1):137-41.

PubMed ID
15488952 [ View in PubMed
]
Abstract

The proteasome is a multi-protein complex that degrades cellular proteins as well as foreign proteins destined for antigen presentation. The latter function involves the immunoproteasome, in which several proteasome subunits are exchanged for gamma-interferon-induced subunits. The transporter associated with antigen processing (TAP) transports proteasome-generated peptides across the membrane of the endoplasmic reticulum (ER) prior to presentation on the plasma membrane. We demonstrate interactions between the cytoplasmic domains of TAP subunits and subunits of both the proteasome and the immunoproteasome, suggesting direct targeting of antigenic peptides to the ER via a TAP-proteasome association. We also show interaction between one of the cytoplasmic domains of P-glycoprotein and a proteasome subunit, but not the corresponding immunoproteasome subunit, suggesting a possible role for P-glycoprotein in the transport of proteasome-derived peptides.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Multidrug resistance protein 1P08183Details
Proteasome subunit beta type-5P28074Details
Antigen peptide transporter 1Q03518Details
Proteasome subunit beta type-8P28062Details