High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.

Article Details

Citation

Hempstead BL, Martin-Zanca D, Kaplan DR, Parada LF, Chao MV

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.

Nature. 1991 Apr 25;350(6320):678-83.

PubMed ID
1850821 [ View in PubMed
]
Abstract

Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and the tyrosine kinase trk gene product. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
High affinity nerve growth factor receptorP04629Details