High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.
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Hempstead BL, Martin-Zanca D, Kaplan DR, Parada LF, Chao MV
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.
Nature. 1991 Apr 25;350(6320):678-83.
- PubMed ID
- 1850821 [ View in PubMed]
- Abstract
Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and the tyrosine kinase trk gene product. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor.