Chiral separation of beta-adrenergic blockers on CelluCoat column by HPLC.

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Ali I, Gaitonde VD, Aboul-Enein HY, Hussain A

Chiral separation of beta-adrenergic blockers on CelluCoat column by HPLC.

Talanta. 2009 Apr 30;78(2):458-63. doi: 10.1016/j.talanta.2008.11.043. Epub 2008 Dec 6.

PubMed ID
19203609 [ View in PubMed
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Abstract

The chiral separation of 10 beta-adrenergic blockers (acebutalol, alprenolol, bufuralol, bisoprolol, celiprolol, carazolol, indenolol, metoprolol, oxprenolol and propranolol) was achieved on CelluCoat column (250 mm x 4.6mm, 5 microm particle size). The mobile phases used were (90:10:0.2, v/v/v) and (95:5:0.2, v/v/v) combinations of n-heptane-ethanol-diethylamine, respectively. The flow rates were 0.5, 1.0 and 2.0 mL min(-1) with detection at 225 nm. The capacity (k), selectivity (alpha) and resolution (R(s)) factors were 0.44-12.91, 1.12-2.19 and 1.00-9.50, respectively. The proposed supra-molecular models indicated that the chiral resolution were governed by pi-pi interactions, hydrogen bondings and steric effect.

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