Efinaconazole: first global approval.

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Patel T, Dhillon S

Efinaconazole: first global approval.

Drugs. 2013 Nov;73(17):1977-83. doi: 10.1007/s40265-013-0152-x.

PubMed ID

24249649 [ View in PubMed

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Abstract

A non-lacquer 10% topical solution of efinaconazole, developed by Valeant Pharmaceuticals International, received its first global approval in Canada in October 2013 for the treatment of onychomycosis. The product is under regulatory review in the US and Japan. The mechanism of anti-fungal activity of efinaconazole, a small-molecule triazole compound, appears to be similar to that of other anti-fungal triazoles, namely ergosterol synthesis inhibition. In particular, it appears to inhibit 14alpha demethylase, an enzyme involved in the conversion of lanosterol to ergosterol, resulting in secondary degenerative changes. This article summarizes the milestones in the development of efinaconazole leading to this first approval for onychomycosis.

DrugBank Data that Cites this Article

Drugs

Efinaconazole

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Efinaconazole	Lanosterol 14-alpha demethylase	Protein		Yes	Inhibitor	Details