Glycogen synthase kinase 3beta (GSK3beta) modulates antiviral activity of zinc-finger antiviral protein (ZAP).

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Citation

Sun L, Lv F, Guo X, Gao G

Glycogen synthase kinase 3beta (GSK3beta) modulates antiviral activity of zinc-finger antiviral protein (ZAP).

J Biol Chem. 2012 Jun 29;287(27):22882-8. doi: 10.1074/jbc.M111.306373. Epub 2012 Apr 18.

PubMed ID
22514281 [ View in PubMed
]
Abstract

Zinc-finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses, including HIV-1, Ebola virus, and Sindbis virus. ZAP binds directly to specific viral mRNAs and recruits cellular mRNA degradation machinery to degrade the target RNA. ZAP has also been suggested to repress translation of the target mRNA. In this study, we report that ZAP is phosphorylated by glycogen synthase kinase 3beta (GSK3beta). GSK3beta sequentially phosphorylated Ser-270, Ser-266, Ser-262, and Ser-257 of rat ZAP. Inhibition of GSK3beta by inhibitor SB216763 or down-regulation of GSK3beta by RNAi reduced the antiviral activity of ZAP. These results indicate that phosphorylation of ZAP by GSK3beta modulates ZAP activity.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Glycogen synthase kinase-3 betaP49841Details